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© 1997 Faculty of Public Health Medicine of the Royal Colleges of Physicians of the United Kingdom

research-article

Immediate colposcopy or cytological surveillance for women with mild dyskaryosis: a cost effectiveness analysis


G. Flannelly
, Research Registrar1,
M. K. Campbell
, Senior Statistician2
P. Meldrum
, Research Assistant3
D. J. Torgerson
, Research Fellow4
A. Templeton
, Professor, Obstetrics and Gynaecology1
H. C. Kitchener
, Consulant, Obstetrics and Gynaecology1

1Department of Obstetrics and Gynaecology, Aberdeen Royal Infirmary Foresterhill, Aberdeen AB25 2ZD
2Health Services Reserch Unit, University of Aberdeen, Medical School Polwarth Building, Foresterhill, Aberdeen AB25 2ZD
3Health Economic Reasearch Unit, University of Aberdeen
4National Primary Care Research and Development Centre, Centre for Health Economics, University of York Heslington, York YO1 5DD


Address correspondence G. Finnely, at Department of Obstetrics and Gynaecology, National Maternity Hospital, Holles Street, Dublin 2, Ireland

BACKGROUND: The aim of the study was to compare the cost effectiveness of immediate diagnosis and treatment of mild dyskaryosis compared with the usual policy of cytological surveillance.

METHODS: A cost effectiveness analysis was carried out alongside a randomized clinical trial.

RESULTS: Immediate diagnosis and treatment increased total costs by 50 per cent from £54.42 per treated woman [95 per cent confidence interval (CI) £48.85–£59.98] in the surveillance group to £82.02 per woman in the immediate diagnosis and treatment group with an incremental cost of £27.60 (95 per cent CI £22.04–£33.17). However, the number of cases of CIN III detected increased by 69 per cent for the policy of immediate diagnosis and treatment. This led to an average cost effectiveness ratio of £180.18 for the immediate diagnosis and treatment group and £199.94 per case of CIN III detected for the surveillance group, with a marginal cost effectiveness ratio of £148.22 (95 per cent Cl £94.01–£309.33) for the immediate diagnosis and treatment group.

CONCLUSION: Immediate diagnosis and treatment increases the total cost of managing mildly dyskaryotic smears but this increased cost is offset by a sharp increase in the number of cases of CIN III detected.

Keywords: mild dyskaryosis, management, cost


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